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SAR-439459

SAR-439459 is a human monoclonal antibody (mAb) targeting TGFB1/TGFβ-1. SAR-439459 blocks TGFβ-mediated pSMAD signaling, and suppression of T cells and NK cells. SAR-439459 has anti-tumor activity [1].

Product Specifications

UNSPSC

12352203

Target

TGF-β Receptor

Related Pathways

TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

[SAR-439459]

References & Citations

[1]Greco R, et al. Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade. Oncoimmunology. 2020 Sep 13;9 (1) :1811605.

Shipping Conditions

Room temperature

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Frequently Asked Questions

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