TXB4

TXB4 is a brain-permeable human monoclonal antibody (mAb) targeting CD71. TXB4 prevents 6-OHDA-induced death of TH-positive neurons in the SNc in a 6-OHDA mouse model of Parkinson's disease (PD) . TXB4 can be used in neurodegenerative diseases, acute brain and spinal cord injury, and depression research[1].

Product Specifications

UNSPSC

12352203

Target

Transferrin Receptor

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

[TXB4]

References & Citations

[1]Clarke E, et al. A Single Domain Shark Antibody Targeting the Transferrin Receptor 1 Delivers a TrkB Agonist Antibody to the Brain and Provides Full Neuroprotection in a Mouse Model of Parkinson's Disease. Pharmaceutics. 2022 Jun 24;14 (7) :1335.