CQY684
CQY684 (PCA062 antibody) is a human monoclonal antibody (mAb) targeting CDH3/P-cadherin. CQY684 stabilizes the X-dimer of P-cadherin, promoting its endocytosis and directing it to lysosomal degradation. CQY684 can be used in Breast, esophageal, and head and neck cancers research[1].
Product Specifications
Product Name Alternative
PCA062 antibody
UNSPSC
12352203
Target
Cadherin
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
[CQY684]
References & Citations
[1]Tam A, et al. Using genome-wide CRISPR screen to understand resistance mechanisms to PCA062, a P-cadherin targeting antibody-drug conjugate[J]. Cancer Research, 2019, 79 (13_Supplement) : 4743-4743.|[2]Xie B, et al. Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody. Nat Commun. 2025 Jan 29;16 (1) :1157.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P991342/
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Curated Selection
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