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MAb604.107

MAb604.107 is a human monoclonal antibody (mAb) targeting NOTCH1. MAb604.107 inhibits the proliferation and CD34/CD44 expression of primary T-ALL cells. MAb604.107 has anti-tumor activity in four tumor xenograft mouse models: MDA-MB-231, HCC-1806, BT-474, and HCT-116. MAb604.107 can be used in T acute lymphoblastic leukemia research[1].

Product Specifications

UNSPSC

12352203

Target

Notch

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

[MAb604.107]

References & Citations

[1]Sharma A, et al. A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors. Sci Rep. 2015 Jun 5;5:11012.

Shipping Conditions

Room temperature

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Frequently Asked Questions

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