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ALG.APV-527

ALG.APV-527 (APV-527) is a bispecific 4-1BB (CD137) and 5T4 antibody. ALG.APV-527 is designed to activate 4-1BB on T and natural killer (NK) cells only when simultaneously bound to 5T4-expressing tumor cells. ALG.APV-527 has a potent antitumor activity[1].

Product Specifications

Product Name Alternative

APV-527; ATOR-1016

UNSPSC

12352203

Target

Transmembrane Glycoprotein

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

[ALG.APV-527]

References & Citations

[1]Nelson MH, et al. The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies. Mol Cancer Ther. 2023 Jan 3;22 (1) :89-101.

Shipping Conditions

Room temperature

Scientific Category

Inhibitory Antibodies

Clinical Information

Phase 2

Frequently Asked Questions

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