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Ichorcumab

Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets Thrombin. Ichorcumab binds to exosite 1 on thrombin and inhibits substrate binding but not catalytic activity. The isotype control for Ichorcumab can refer to Human IgG4 kappa, Isotype Control.

Product Specifications

CAS Number

2589583-20-8

Product Name Alternative

JNJ-375; JNJ-64179375; JNJ-9375

UNSPSC

12352203

Target

Thrombin

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

95.33

Smiles

[Ichorcumab]

Molecular Weight

(146.260 kDa)

References & Citations

[1]Weitz JI, et al. Randomized phase 2 trial comparing JNJ-9375, a thrombin-directed antibody, with apixaban for prevention of venous thrombosis. J Thromb Haemost. 2019 Dec;17 (12) :2081-2088.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C

Scientific Category

Inhibitory Antibodies

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

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