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Atigotatug (FUT8-KO)

Atigotatug (FUT8-KO) is an anti-fuc-GM1 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out, and fucose deficiency enhances the ADCC effect of the antibody. Atigotatug is a Fucosyl ganglioside GM1 (fuc-GM1) -targeting IgG1κ type humanized antibody. Atigotatug can induce immune-mediated tumor cell death, such as small cell lung cancer[1].

Product Specifications

CAS Number

2733581-82-1

Product Name Alternative

BMS-986012 (FUT8-KO)

UNSPSC

12352203

Target

Others

Related Pathways

Others

Field of Research

Cancer

Smiles

[Atigotatug(FUT8-KO)]

References & Citations

[1]Paz-Ares L G, et al. The TIGOS trial: A randomized, double-blind phase 3 trial of atigotatug+ nivolumab fixed-dose combination with chemotherapy vs atezolizumab with chemotherapy in patients with 1L extensive-stage small cell lung cancer (ES-SCLC) [J]. 2025.

Shipping Conditions

Room temperature

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Frequently Asked Questions

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