Atigotatug (FUT8-KO)
Atigotatug (FUT8-KO) is an anti-fuc-GM1 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out, and fucose deficiency enhances the ADCC effect of the antibody. Atigotatug (HY-P990902) is a Fucosyl ganglioside GM1 (fuc-GM1) -targeting IgG1κ type humanized antibody. Atigotatug can induce immune-mediated tumor cell death, such as small cell lung cancer[1].
Product Specifications
CAS Number
[2733581-82-1]
Product Name Alternative
BMS-986012 (FUT8-KO)
UNSPSC
12352203
Target
Others
Related Pathways
Others
Field of Research
Cancer
Smiles
[Atigotatug(FUT8-KO)]
References & Citations
[1]Paz-Ares L G, et al. The TIGOS trial: A randomized, double-blind phase 3 trial of atigotatug+ nivolumab fixed-dose combination with chemotherapy vs atezolizumab with chemotherapy in patients with 1L extensive-stage small cell lung cancer (ES-SCLC) [J]. 2025.
Shipping Conditions
Room temperature
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Curated Selection
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