Anti-PERP Antibody

Rabbit Polyclonal Antibody specific to PERP

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Keratinocyte-associated protein 1, KCP-1, P53-induced protein PIGPC1, Transmembrane protein THW

Gene Name

PERP

NCBI Gene ID

UniProt

Q96FX8

Cellular Locus

Cell junction, desmosome, Cell membrane

Host

Rabbit

Reactivity

Human

Immunogen

Peptide corresponding to aa 175-193 of human PERP. This sequence differs from that of mouse by three amino acids.

Target Antigen

p53 apoptosis effector related to PMP-22

Target

PERP

Clonality

Polyclonal

Type

Antibody

Applications

ELISA, WB, ICC

Field of Research

Cancer research

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. {UniProtKB:Q9JK95}.; Plays a role as an effector in the TP53-dependent apoptotic pathway. {UniProtKB:Q9JK95}.

Additionnal Information

Immunoblotting: use at 0.5-1 ug/mL. In immunoblots, a band of 21 kD is detected. <br><br>Positive control: A431 cell lysate.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes human PERP, a plasma membrane protein involved in the p53 network. p53 binds to the promoter of PERP and transcriptionally activates the PERP gene; the translated PERP protein mediates p53-induced apoptosis leading to cell death.