PROTAC AR-V7 degrader-1
Product Specifications
UNSPSC Description
PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC50 of 0.32 µM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC50 of 0.88 µM[1].
Target Antigen
Androgen Receptor; PROTACs
Type
Reference compound
Related Pathways
PROTAC;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-ar-v7-degrader-1.html
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
O=C(CCCCOC1=CC=C(C2=CSC(N3CCOCC3)=N2)C=C1)N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C=C5)C6=C(N=CS6)C)C)=O)=O
Molecular Weight
789.02
References & Citations
[1]Archana Bhumireddy, et al. Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders. Bioorg Med Chem Lett. 2022 Jan 1;55:128448.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145479/PROTAC-AR-V7-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145479/PROTAC-AR-V7-degrader-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2767440-24-2
Available Sizes
Curated Selection
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