Klotho beta, Human (968a.a, HEK293, His)

Klotho beta protein plays a critical role in the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), a key enzyme controlling bile acid synthesis. Although its glycosidase activity may be inactive, Klotho beta enhances the binding ability of FGFR1 and FGFR4 to FGF21, promoting their interaction. Klotho beta Protein, Human (968a.a, HEK293, His) is the recombinant human-derived Klotho beta protein, expressed by HEK293, with C-His labeled tag.