GCO- (GPO) 10-GCOG

GCO- (GPO) 10-GCOG is a GPO repeat-containing peptide with a single collagen triple helix structure similar to collagen. The cross-linked triple helix GCO- (GPO) 10-GCOG can form a collagen-related peptide (CRP) mimetic that tightly binds to the Yersinia adhesin YadA. YadA mediates the adhesion of the human enteric pathogen Yersinia enterocolitica to collagen and other extracellular matrix components, potentially interfering with host processes mediated by endogenous collagen-binding proteins in vivo. GCO- (GPO) 10-GCOG can be used to study YadA-associated infections[1].

Product Specifications

UNSPSC

12352209

Target

Bacterial

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(N[C@@H](CS)C(N1[C@@H](CC(C1)O)C(NCC(N2[C@@H](CCC2)C(N3[C@@H](CC(C3)O)C(NCC(N4[C@@H](CCC4)C(N5[C@@H](CC(C5)O)C(NCC(N6[C@@H](CCC6)C(N7[C@@H](CC(C7)O)C(NCC(N8[C@@H](CCC8)C(N9[C@@H](CC(C9)O)C(NCC(N%10[C@@H](CCC%10)C(N%11[C@@H](CC(C%11)O)C(NCC(N%12[C@@H](CCC%12)C(N%13[C@@H](CC(C%13)O)C(NCC(N%14[C@@H](CCC%14)C(N%15[C@@H](CC(C%15)O)C(NCC(N%16[C@@H](CCC%16)C(N%17[C@@H](CC(C%17)O)C(NCC(N%18[C@@H](CCC%18)C(N%19[C@@H](CC(C%19)O)C(NCC(N%20[C@@H](CCC%20)C(N%21[C@@H](CC(C%21)O)C(NCC(N[C@@H](CS)C(N%22[C@@H](CC(C%22)O)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C142H205N37O50S2

Molecular Weight

3294.53

References & Citations

[1]Leo JC, et al. First analysis of a bacterial collagen-binding protein with collagen Toolkits: promiscuous binding of YadA to collagens may explain how YadA interferes with host processes. Infect Immun. 2010 Jul;78 (7) :3226-36.