Z-Val-Val-Nle-diazomethylketone
Z-Val-Val-Nle-diazomethylketone is a cathepsin S (CATS) inhibitor. Z-Val-Val-Nle-diazomethylketone significantly inhibits the IFNg-induced upregulation of the MHCII molecules HLA-DR and Ii-p33/35 with an increase of Ii-p10 protein level. Z-Val-Val-Nle-diazomethylketone can be used for dermatological diseases like psoriasis, atopic dermatitis and actinic keratosis research[1].
Product Specifications
CAS Number
[155026-49-6]
Product Name Alternative
Z-Val-Val-Nle-CHN2
UNSPSC
12352209
Target
Cathepsin; MHC
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCC)C(C=[N+]=[N-])=O)=O)=O
Molecular Formula
C25H37N5O5
Molecular Weight
487.59
References & Citations
[1]Schönefuss A, et al. Upregulation of cathepsin S in psoriatic keratinocytes. Exp Dermatol. 2010 Aug;19 (8) :e80-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Cathepsin C; MHC II
Available Sizes
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