YVAD-CHO (TFA)
YVAD-CHO TFA is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (Ki: 0.76 nM) . YVAD-CHO TFA inhibits mature IL-1β production. YVAD-CHO TFA partially delays motoneurone death in lesioned facial nerve mice[1][2].
Product Specifications
UNSPSC
12352209
Target
Caspase; Interleukin Related
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C=O)=O)=O)[C@H](CC1=CC=C(C=C1)O)N.FC(C(O)=O)(F)F.[x]
Molecular Weight
450.49 (free base)
References & Citations
[1]de Bilbao F, et al. Acute application of an interleukin-1 beta-converting enzyme-specific inhibitor delays axotomy-induced motoneurone death. Neuroreport. 1996 Nov 25;7 (18) :3051-4.|[2]Laliberte RE, et al. ATP treatment of human monocytes promotes caspase-1 maturation and externalization. J Biol Chem. 1999 Dec 24;274 (52) :36944-51.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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