YVAD-CHO (TFA)

YVAD-CHO TFA is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (Ki: 0.76 nM) . YVAD-CHO TFA inhibits mature IL-1β production. YVAD-CHO TFA partially delays motoneurone death in lesioned facial nerve mice[1][2].

Product Specifications

UNSPSC

12352209

Target

Caspase; Interleukin Related

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C=O)=O)=O)[C@H](CC1=CC=C(C=C1)O)N.FC(C(O)=O)(F)F.[x]

Molecular Weight

450.49 (free base)

References & Citations

[1]de Bilbao F, et al. Acute application of an interleukin-1 beta-converting enzyme-specific inhibitor delays axotomy-induced motoneurone death. Neuroreport. 1996 Nov 25;7 (18) :3051-4.|[2]Laliberte RE, et al. ATP treatment of human monocytes promotes caspase-1 maturation and externalization. J Biol Chem. 1999 Dec 24;274 (52) :36944-51.