Boc-AEVD-CHO (TFA)

Boc-AEVD-CHO TFA is a Caspase 8 inhibitor. Boc-AEVD-CHO TFA significantly increases the frequencies of Nocodazole (HY-13520) or methyl methane sulfonate (MMS) induced micronuclei (MN) and micronucleated binucleates (MNCB) in PBMC by inhibiting cell apoptosis. Boc-AEVD-CHO TFA can be used for immune and inflammatory diseases research[1].

Product Specifications

UNSPSC

12352209

Target

Apoptosis; Caspase

Related Pathways

Apoptosis

Field of Research

Inflammation/Immunology

Smiles

C[C@H](NC(OC(C)(C)C)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C=O)CC(O)=O)=O)=O)=O.FC(C(O)=O)(F)F.[x]

Molecular Formula

C22H36N4O10.xC2HF3O2

Molecular Weight

516.54 (free base)

References & Citations

[1]Decordier I, et al. Influence of caspase activity on micronuclei detection: a possible role for caspase-3 in micronucleation. Mutagenesis. 2005 May;20 (3) :173-9.