Biotin-DEVD-CHO (TFA)
Biotin-DEVD-CHO (TFA) is a biotin-conjugated form of the caspase-3 and -7 inhibitor – Ac-DEVD-CHO. Biotin-DEVD-CHO (TFA) can be used for affinity purification of the active caspase-3, -6, -7, and -8. Biotin-DEVD-CHO (TFA) can detect the active caspase-3 in vitro[1][2][3][4].
Product Specifications
UNSPSC
12352209
Target
Caspase; Orexin Receptor (OX Receptor)
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling
Field of Research
Others
Smiles
OC(CC[C@@H](C(N[C@H](C(N[C@@H](CC(O)=O)C=O)=O)C(C)C)=O)NC([C@@H](NC(CCCC[C@@H]1[C@]2([H])NC(N[C@@]2(CS1)[H])=O)=O)CC(O)=O)=O)=O.FC(C(O)=O)(F)F
Molecular Formula
C30H43F3N6O14S
Molecular Weight
800.75
References & Citations
[1]Nicholson, D. W., et al., (1995) . Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature, 376 (6535), 37–43. |[2]Kumar, S., & Dorstyn, L. (2009) . Analysing caspase activation and caspase activity in apoptotic cells. Methods in molecular biology (Clifton, N.J.), 559, 3–17. |[3]Suria, H., et al., (1999) . Cytoskeletal disruption induces T cell apoptosis by a caspase-3 mediated mechanism. Life sciences, 65 (25), 2697–2707.|[4]Sohn, D., et al., (2005) . Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. The Journal of biological chemistry, 280 (7), 5267–5273.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5830A/
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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