Endothelin (16-21)

Endothelin (16-21) is a selective ETB receptor agonist (EC50=228 nM in guinea-pig bronchus) . Endothelin (16-21) can induce smooth muscle contraction. Endothelin (16-21) is promising for research of respiratory (e.g., asthma) and cardiovascular (e.g., hypertension) diseases[1][2].

Product Specifications

CAS Number

[121377-67-1]

UNSPSC

12352209

Target

Endothelin Receptor

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

N[C@@H](CC1=CN=CN1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O

Molecular Formula

C39H57N9O9

Molecular Weight

795.92

References & Citations

[1]Maggi CA, et al. The C-terminal hexapeptide, endothelin- (16-21), discriminates between different endothelin receptors. Eur J Pharmacol. 1989 Jul 4;166 (1) :121-2.|[2]Douglas SA, et al. Endothelium-dependent mesenteric vasorelaxant effects and systemic actions of endothelin (16-21) and other endothelin-related peptides in the rat. Br J Pharmacol. 1991 Oct;104 (2) :311-20.