GAD65 (524-543) (acetate)

GAD65 (524-543) acetate is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65) . GAD65 (524-543) acetate is one of the first fragments of the islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) acetate is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) acetate increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells[1].

Product Specifications

UNSPSC

12352209

Target

Amino Acid Decarboxylase

Related Pathways

Neuronal Signaling

Field of Research

Others

Purity

98.08

Smiles

OC1=CC=C(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]2N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CO)N)=O)=O)CC(C)C)=O)CO)=O)CCCCN)=O)C(C)C)=O)C)=O)CCC2)=O)C(C)C)=O)[C@H](CC)C)=O)CCCCN)=O)C)=O)CCCNC(N)=N)=O)CCSC)=O)CCSC)=O)CCC(O)=O)=O)C(NCC(N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)[C@@H](C)O)=O)=O)C=C1.CC(O)=O.[x]

Molecular Formula

C97H168N28O28S2.xC2H4O2

Molecular Weight

2238.67 (free base)

References & Citations

[1]Dai YD, et al. A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas. J Immunol. 2005 Sep 15;175 (6) :3621-7.