TNO211 (TFA)

TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu (EDANS) -Ala-Lys-NH2) TFA is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 TFA can specifically detect MMP activity (Ex/Em = 340/485 nm) [1].

Product Specifications

Product Name Alternative

Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu (EDANS) -Ala-Lys-NH2 (TFA)

UNSPSC

12352209

Target

Fluorescent Dye; MMP

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

FC(C(O)=O)(F)F.O=S(O)(C1=CC=CC2=C1C=CC=C2NCCNC(CC[C@@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CCCCN)=O)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CCC(N)=O)NC([C@H]3N(CCC3)C(CCCNC(C4=CC=C(C=C4)/N=N/C5=CC=C(C=C5)N(C)C)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C65H89F3N16O16S

Molecular Weight

1439.56

References & Citations

[1]Beekman B, et al. Convenient fluorometric assay for matrix metalloproteinase activity and its application in biological media. FEBS Lett. 1996 Jul 22;390 (2) :221-5.