Palmitoyl tetrapeptide-20 (TFA)

Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 TFA promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC50: 0.16 nM), enhancing catalase activity to reduce H2O2 accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 TFA can be used in research on preventing hair loss and improving hair graying[1].

Product Specifications

Product Name Alternative

PTP20 (TFA)

UNSPSC

12352209

Target

Melanocortin Receptor; Sirtuin

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

OC(C(F)(F)F)=O.CCCCCCCCCCCCCCCC(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCCCN)=O)CCC(O)=O)=O)CCC1)=O.[x]

Molecular Formula

C38H70N6O8.xC2HF3O2

Molecular Weight

739.00 (free base)

References & Citations

[1]Almeida Scalvino S, et al. Efficacy of an agonist of α-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation. Int J Cosmet Sci. 2018 Oct;40 (5) :516-524.