Palmitoyl tetrapeptide-20 (TFA)
Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 TFA promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC50: 0.16 nM), enhancing catalase activity to reduce H2O2 accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 TFA can be used in research on preventing hair loss and improving hair graying[1].
Product Specifications
Product Name Alternative
PTP20 (TFA)
UNSPSC
12352209
Target
Melanocortin Receptor; Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.CCCCCCCCCCCCCCCC(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCCCN)=O)CCC(O)=O)=O)CCC1)=O.[x]
Molecular Formula
C38H70N6O8.xC2HF3O2
Molecular Weight
739.00 (free base)
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC1R; SIRT1
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