Tetrapeptide-21

Tetrapeptide-21 is a bioactive peptide composed of four amino acids. Tetrapeptide-21 effectively enhances the vitality of human dermal fibroblasts. Tetrapeptide-21 upregulates the expression of key extracellular matrix (ECM) genes and promotes the synthesis of ECM proteins (such as type I collagen, hyaluronic acid synthase 1, and fibronectin) . Tetrapeptide-21 has the efficacy of anti-wrinkle and improving skin elasticity, and has been reported to be used as a cosmetic ingredient[1][2].

Product Specifications

CAS Number

960608-17-7

UNSPSC

12352209

Target

Collagen

Related Pathways

Cytoskeleton

Field of Research

Metabolic Disease

Purity

98.87

Solubility

H2O : ≥ 200 mg/mL

Smiles

NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(NCC(O)=O)=O)=O)=O

Molecular Formula

C15H27N5O7

Molecular Weight

389.40

References & Citations

[1]Beldio Research GmbH, et al. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics 2017, 4 (2), 16|[2]Paccola AGL, et al. Synergistic Effects of Injectable Platelet-Rich Fibrin and Bioactive Peptides on Dermal Fibroblast Viability and Extracellular Matrix Gene Expression: An In Vitro Study. Molecules. 2025 Aug 19;30 (16) :3415.