Phlotoxin-1 (TFA)

O=C([C@@H](N)C)N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)CC(C)C)=O)CCCCN)=O)CC5=CC=C(O)C=C5)=O)CCCNC(N)=N)=O)=O)CCCCN)=O)CO)=O)C)=O)CCCCN)=O)CCC1)=O)CC(O)=O)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N7[C@H](C(N[C@H]3CC8=CNC9=CC=CC=C89)=O)CCC7)=O)CC%10=CC=C(O)C=C%10)=O)CCCCN)=O)CC%11=CNC%12=CC=CC=C%11%12)=O)CCC(O)=O)=O)=O)CO)=O)CC(O)=O)=O)CC%13=CNC%14=CC=CC=C%13%14)=O)CCC(N)=O)=O)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N%15[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6C)=O)CC%16=CC=C(O)C=C%16)=O)CC(N)=O)=O)CCC%15)=O.OC(C(F)(F)F)=O.[x]

[1]Gonçalves TC, et al. Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates. Toxins (Basel) . 2019 Aug 22;11 (9) :484.|[2]Nicolas S, et al. Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel) . 2019 Jun 21;11 (6) :367.