ω-Hexatoxin-Hv1a (TFA)

ω-Hexatoxin-Hv1a TFA (ω-ACTX-Hv1 TFA) is a neurotoxin that can be isolated from the venom spider (Hadronyche versuta) .ω-Hexatoxin-Hv1a TFA blocks voltage-gated calcium channels. ω-Hexatoxin-Hv1a TFA can be used in the research of Myzus persicae infections[1][2].

Product Specifications

Product Name Alternative

ω-ACTX-Hv1 (TFA) ; ω-Atracotoxin-HV1 (TFA)

UNSPSC

12352209

Target

Calcium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Smiles

O=C([C@@H](N)CO)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(NCC(N[C@H](C(N3[C@H](C(N[C@H](C(N4C(C(NC(C(NC(C(NC(C(NC(C(N[C@H]5CSSC[C@H](NC6=O)C(N[C@H](C(O)=O)CC(O)=O)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)CC(N)=O)=O)CC7=CC=C(O)C=C7)=O)CCC4)=O)CSSC[C@H](NC8=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6CCCNC(N)=N)=O)CCCCN)=O)C(C)C)=O)[C@@H](C)O)=O)CC(N)=O)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)CCCCN)=O)CC9=CC=CC=C9)=O)[C@@H](C)O)=O)=O)CCC3)=O)CCC(N)=O)=O)=O)CO)=O)CCC2)=O)[C@H](CC)C)=O)CSSC[C@H](NC5=O)C(N[C@H](C(N[C@H](C(N[C@H]8CO)=O)CCC(N)=O)=O)CO)=O)=O)[C@@H](C)O)=O)CCC1.OC(C(F)(F)F)=O.[x]

Molecular Formula

C162H247N49O61S6·xC2HF3O2

Molecular Weight

4049.38 (free base)

References & Citations

[1]Powell ME, et al. Demonstrating the potential of a novel spider venom-based biopesticide for target-specific control of the small hive beetle, a serious pest of the European honeybee. J Pest Sci (2004) . 2020;93 (1) :391-402.|[2]Yang S, et al. Effect of insecticidal fusion proteins containing spider toxins targeting sodium and calcium ion channels on pyrethroid-resistant strains of peach-potato aphid (Myzus persicae) . Pest Manag Sci. 2015 Jul;71 (7) :951-6.