Mca-KPLGL-Dap (Dnp) -AR-NH2 (TFA)

Mca-KPLGL-Dap (Dnp) -AR-NH2 TFA is a fluorogenic substrate for matrix metalloproteinases (MMPs) . 7-methoxycoumarin-4 acetyl (Mac) is released and its fluorescence can be used to quantify MMP activity. Mac displays Ex/Em of 328/420 nm[1].

Product Specifications

CAS Number

[1392300-20-7]

UNSPSC

12352209

Target

Fluorescent Dye

Related Pathways

Others

Field of Research

Others

Smiles

O=C([C@H]1N(C([C@H](CCCCN)NC(CC(C2=C(O3)C=C(OC)C=C2)=CC3=O)=O)=O)CCC1)N[C@@H](CC(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CNC4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F

Molecular Formula

C57H81F3N16O18

Molecular Weight

1335.34

References & Citations

[1]Ulf Neumann, et al. Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme. Comparative Study Anal Biochem. 2004 May 15;328 (2) :166-73.