Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2

Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 (compound 5) is a selective hMC5R antagonist ligand with an IC50 of 10 nM[1].

Product Specifications

CAS Number

[596135-92-1]

UNSPSC

12352209

Target

Melanocortin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(N[C@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N1)=O)CCCNC(N)=N)=O)CC2=CC=CC=C2)=O)CC3=CN=CN3)=O)CCC(O)=O)=O)NC(C)=O)C(N4[C@@H](CCC4)C(N5[C@@H](CCC5)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC(O)=O)=O)=O)=O)=O)[C@@H]1CC6=CNC7=CC=CC=C67

Molecular Formula

C65H89N19O16S2

Molecular Weight

1456.65

References & Citations

[1]Balse-Srinivasan P, et al. Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R. J Med Chem. 2003 Aug 14;46 (17) :3728-33.|[2]Balse-Srinivasan P, et al. Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R. J Med Chem. 2003 Aug 14;46 (17) :3728-33.