Z-VEID-AFC (TFA)

Z-VEID-AFC TFA is the trifluoroacetate salt of Z-VEID-AFC (HY-P4401) . Z-VEID-AFC TFA is a fluorescent substrate for caspase-6. When Z-VEID-AFC TFA is cleaved by caspase-6, 7-amino-4-trifluoromethylcoumarin (AFC) is released, and its fluorescence can be used to quantify caspase-6 activity (Ex/Em: 400/505 nm) [1][2].

Product Specifications

UNSPSC

12352209

Target

Caspase; Fluorescent Dye

Related Pathways

Apoptosis; Others

Field of Research

Others

Smiles

FC(C(O)=O)(F)F.FC(F)(C(C1=CC=C(NC([C@H](CC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC(OCC2=CC=CC=C2)=O)=O)=O)=O)=O)C=C1O3)=CC3=O)F

Molecular Formula

C40H45F6N5O14

Molecular Weight

933.80

References & Citations

[1]Vikas Kaushal, et al. Inflammasome-mediated activation of caspase-1 and caspase-6 in primary human neurons.Volume8, Issue4S_Part_8.Alzheimer 's Association International Conference 2012.|[2]Li L, et al. Involvement of specific caspases in motoneuron cell death in vivo and in vitro following trophic factor deprivation. Mol Cell Neurosci. 1998 Oct;12 (3) :157-67.