β-Amyloid (1-38) (TFA)
β-Amyloid (1-38) (Aβ (1-38) ) TFA is a β-Amyloid (Aβ) peptide. β-Amyloid (1-38) TFA interferes with the conversion of Aβ (1-42) to a β-sheet-rich aggregate. β-Amyloid (1-38) TFA reverses the negative impact of Aβ (1-42) on long-term potentiation in acute hippocampal slices and on membrane conductance in primary neurons, and mitigates an Aβ (1-42) phenotype in Caenorhabditis elegans[1].
Product Specifications
Product Name Alternative
Aβ (1-38) (TFA) ; Aβ38 (TFA)
UNSPSC
12352209
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Purity
99.38
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(NCC(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(NCC(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N.OC(C(F)(F)F)=O.[x]
Molecular Formula
C184H277N51O56S.xC2HF3O2
Molecular Weight
4131.54 (free base)
References & Citations
[1]Maa O Quartey, et al. The Aβ (1-38) peptide is a negative regulator of the Aβ (1-42) peptide implicated in Alzheimer disease progression. Sci Rep. 2021 Jan 11;11 (1) :431.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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