JKC 302

JKC 302 is an ET-A receptor antagonist. JKC 302 partly blocks ET-1-induced contraction in asthmatic rat trachea ring[1][2].

Product Specifications

CAS Number

[153982-38-8]

UNSPSC

12352209

Target

Endothelin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Smiles

O=C(N[C@@H](C(N1[C@](CCC1)([H])C(N[C@@H](C(N[C@H](C(N2)=O)CC(C)C)=O)C(C)C)=O)=O)CO)[C@H]2CC3=CNC4=CC=CC=C34

Molecular Formula

C30H42N6O6

Molecular Weight

582.69

References & Citations

[1]Basilico N, et al. The lipid moiety of haemozoin (Malaria Pigment) and P. falciparum parasitised red blood cells bind synthetic and native endothelin-1. J Biomed Biotechnol. 2010;2010:854927.|[2]Tiequn HUANG, et al. Role of endothelin and nitric oxide in the pathogenesis of asthma. Chinese Journal of Pathophysiology ; (12) : 435-437, 2001.