JB-1

JB-1, an IGF-1 peptide analog, is a selective and potent IGF-1R antagonist. JB-1 competes with IGF-1 by binding the IGF-1 receptor. JB-1 prevents the autophosphorylation of IGF-1R, and has no activity in IGF-II[1].

Product Specifications

CAS Number

[147819-32-7]

UNSPSC

12352209

Target

IGF-1R

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

99.63

Solubility

H2O : 100 mg/mL

Smiles

O=C1N2[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@](CCC3)([H])C(N[C@H](C(N[C@H]1CCCCN)=O)CC(C)C)=O)=O)C)=O)C)=O)CC4=CC=C(C=C4)O)=O)N)C(O)=O)=O)CO)=O)CCCCN)=O)C)=O)([H])CCC2

Molecular Formula

C55H88N14O15S2

Molecular Weight

1249.50

References & Citations

[1]Brock RS, et al. Biomolecular effects of JB1 (an IGF-I peptide analog) in a rat model of oxygen-induced retinopathy. Pediatr Res. 2011 Feb;69 (2) :135-41.