JB-1
JB-1, an IGF-1 peptide analog, is a selective and potent IGF-1R antagonist. JB-1 competes with IGF-1 by binding the IGF-1 receptor. JB-1 prevents the autophosphorylation of IGF-1R, and has no activity in IGF-II[1].
Product Specifications
CAS Number
147819-32-7
UNSPSC
12352209
Target
IGF-1R
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.63
Solubility
H2O : 100 mg/mL
Smiles
O=C1N2[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@](CCC3)([H])C(N[C@H](C(N[C@H]1CCCCN)=O)CC(C)C)=O)=O)C)=O)C)=O)CC4=CC=C(C=C4)O)=O)N)C(O)=O)=O)CO)=O)CCCCN)=O)C)=O)([H])CCC2
Molecular Formula
C55H88N14O15S2
Molecular Weight
1249.50
References & Citations
[1]Brock RS, et al. Biomolecular effects of JB1 (an IGF-I peptide analog) in a rat model of oxygen-induced retinopathy. Pediatr Res. 2011 Feb;69 (2) :135-41.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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