Dnp-RPLALWRS (TFA)

Dnp-RPLALWRS TFA is a fluorescent peptide substrate designed for human matrilysin (MMP-7) . After enzymatic cleavage of Dnp-RPLALWRS TFA at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS TFA provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin[1].

Product Specifications

UNSPSC

12352209

Target

Fluorescent Dye

Related Pathways

Others

Field of Research

Others

Purity

99.04

Smiles

OC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H]3N(C([C@H](CCCNC(N)=N)NC4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)=O)CCC3)=O)=O)=O)=O)=O)=O.FC(C(O)=O)(F)F

Molecular Formula

C54H78F3N17O16

Molecular Weight

1278.30

References & Citations

[1]Welch AR, et al. Purification of human matrilysin produced in Escherichia coli and characterization using a new optimized fluorogenic peptide substrate. Arch Biochem Biophys. 1995 Dec 1;324 (1) :59-64.