Alkaline Phosphatase, Calf intestinal

Alkaline Phosphatase (Apase), Calf intestinal is an alkaline phosphatase from Calf intestinal, and is one of the most active alkaline phosphatases. Alkaline Phosphatase, Calf intestinal is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline Phosphatase, Calf intestinal reduces myeloperoxidase activity and bacterial translocation. Alkaline Phosphatase, Calf intestinal improves survival rate of mice infected with E. coli. Alkaline Phosphatase, Calf intestinal improves TNBS-induced colon inflammation[1][2][3][4][5][6].

Product Specifications

CAS Number

[9001-78-9]

Product Name Alternative

Apase, Calf intestinal

UNSPSC

12352204

Target

Bacterial; Endogenous Metabolite; Glutathione Peroxidase; Phosphatase

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Smiles

[AlkalinePhosphatase,Calfintestinal]

References & Citations

[1]Beumer C, et al. Calf intestinal alkaline phosphatase, a novel therapeutic drug for lipopolysaccharide (LPS) -mediated diseases, attenuates LPS toxicity in mice and piglets. J Pharmacol Exp Ther. 2003 Nov;307 (2) :737-44.|[2]van Veen SQ, et al. Bovine intestinal alkaline phosphatase attenuates the inflammatory response in secondary peritonitis in mice. Infect Immun. 2005 Jul;73 (7) :4309-14.|[3]Hyoju SK, et al. Intestinal alkaline phosphatase decreases intraperitoneal adhesion formation. J Surg Res. 2017 Feb;208:84-92.|[4]Martínez-Moya P, et al. Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats. Pharmacol Res. 2012 Aug;66 (2) :144-53.|[5]Ujjawal Sharma, et al. Alkaline Phosphatase: An Overview. Indian J Clin Biochem. 2014 Jul; 29 (3) : 269-278.|[6]Chirambo GM, et al. The role of alkaline phosphatase in intracellular lipid accumulation in the human hepatocarcinoma cell line, HepG2. Exp Mol Pathol. 2017 Apr;102 (2) :224-229.