Dihydrochlamydocin analog-1
Dihydrochlamydocin analog-1 (compound 2) is a Chlamydocin (HY-115761) analogue that inhibits histone H4 peptide deacetylation with IC50 of 30 nM[1].
Product Specifications
CAS Number
[157618-75-2]
UNSPSC
12352209
Hazard Statement
H302+H312+H332
Target
HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N2[C@@](CCC2)([H])C(N[C@H](C(NC(C)(C(N[C@H]1CC3=CC=CC=C3)=O)C)=O)CCCCCC([C@H](O)C)=O)=O
Molecular Formula
C28H40N4O6
Molecular Weight
528.64
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
References & Citations
[1]Simone Di Micco, et al. Molecular modeling studies toward the structural optimization of new cyclopeptide-based HDAC inhibitors modeled on the natural product FR235222. Bioorg Med Chem. 2008 Sep 15;16 (18) :8635-42.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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