Cyclo (L-leucyl-L-tryptophyl)

Cyclo (L-leucyl-L-tryptophyl) (Cyclo (-Leu-Trp) ) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo (L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand[1][2][3].

Product Specifications

CAS Number

[15136-34-2]

Product Name Alternative

Cyclo (Leu-Trp)

UNSPSC

12352209

Target

Bacterial; Fungal; Melatonin Receptor

Related Pathways

Anti-infection; GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Purity

99.90

Smiles

O=C(N[C@H](C(N1)=O)CC(C)C)[C@@H]1CC2=CNC3=CC=CC=C23

Molecular Formula

C17H21N3O2

Molecular Weight

299.37

References & Citations

[1]Shiba T, et al. Some aspects of the relationship between the structure of a bitter diketopiperazine and its receptor. Biopolymers. 1981 Sep;20 (9) :1985-7. |[2]Kumar SN, et al. Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria. Peptides. 2014 Mar;53:48-58.|[3]Zubare-Samuelov M, et al. Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores. Am J Physiol Cell Physiol. 2003 Nov;285 (5) :C1255-62.