Teduglutide-Leu (13C6,15N) (sodium)

Teduglutide-Leu (13C6,15N) (ALX-0600-Leu (13C6,15N) ) sodium is the 13C- and 15N-labeled Teduglutide (HY-P1624) . Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2) . Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1) /nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis[1][2][3][4].

Product Specifications

Product Name Alternative

ALX-0600-Leu (13C6,15N) (sodium)

UNSPSC

12352209

Target

FXR; Isotope-Labeled Compounds; Nuclear Hormone Receptor 4A/NR4A

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C([C@@H](N)CC1=CNC=N1)NCC(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C([15NH][13C@H]([13C](N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)CCCCN)=O)[C@@H](C)O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)CC2=CNC3=CC=CC=C23)=O)CC(N)=O)=O)[C@H](CC)C)=O)CC4=CC=CC=C4)=O)CC(O)=O)=O)CCCNC(N)=N)=O)C)=O)C)=O)CC(C)C)=O)CC(N)=O)=O)CC(O)=O)=O)[13CH2][13CH]([13CH3])[13CH3])=O)[C@H](CC)C)=O)[C@@H](C)O)=O)CC(N)=O)=O)CCSC)=O)CCC(O)=O)=O)CC(O)=O)=O)CO)=O)CC5=CC=CC=C5)=O)CO)=O)=O)CC(O)=O)=O.[x].[Na]

Molecular Formula

C158 13C6H252N43 15NO55S·xNa

Molecular Weight

3759.03 (free base)

References & Citations

[1]Reiner J, et al. Teduglutide Promotes Epithelial Tight Junction Pore Function in Murine Short Bowel Syndrome to Alleviate Intestinal Insufficiency. Dig Dis Sci. 2020 Dec;65 (12) :3521-3537. |[2]Arda-Pirincci P, et al. Teduglutide, a glucagon-like peptide 2 analogue: a novel protective agent with anti-apoptotic and anti-oxidant properties in mice with lung injury. Peptides. 2012 Dec;38 (2) :238-47. |[3]Nuzzo D, et al. Glucagon-like peptide-2 reduces the obesity-associated inflammation in the brain. Neurobiol Dis. 2019 Jan;121:296-304. |[4]Fuchs CD, et al. GLP-2 Improves Hepatic Inflammation and Fibrosis in Mdr2-/- Mice Via Activation of NR4a1/Nur77 in Hepatic Stellate Cells and Intestinal FXR Signaling. Cell Mol Gastroenterol Hepatol. 2023;16 (5) :847-856.