TDFA

TDFA is an irreversible inhibitor of protein arginine deiminase 4 (PAD4) .

Product Specifications

CAS Number

[1345019-64-8]

Product Name Alternative

Thr-Asp-F-amidine

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

Protein Arginine Deiminase

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O[C@@H]([C@@H](C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CCCNC(CF)=N)=O)=O)NC(C)=O)C

Molecular Formula

C17H29FN6O7

Molecular Weight

448.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, Coonrod SA, Guo M, Thompson PR. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem Biol. 2012 Jan 20;7 (1) :160-5.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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