TDFA
TDFA is an irreversible inhibitor of protein arginine deiminase 4 (PAD4) .
Product Specifications
CAS Number
[1345019-64-8]
Product Name Alternative
Thr-Asp-F-amidine
UNSPSC
12352209
Hazard Statement
H302-H315-H319-H335
Target
Protein Arginine Deiminase
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O[C@@H]([C@@H](C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CCCNC(CF)=N)=O)=O)NC(C)=O)C
Molecular Formula
C17H29FN6O7
Molecular Weight
448.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, Coonrod SA, Guo M, Thompson PR. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem Biol. 2012 Jan 20;7 (1) :160-5.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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