Ac-IETD-AFC (TFA)
Ac-IETD-AFC TFA is a synthetic fluorogenic substrate that can be used to specifically detect caspase-8 activity. INDO 1 pentasodium is imbued with the fluorophore AFC (7-amino-4-trifluoromethylcoumarin) . When caspase-8 recognizes and cleaves the amide bond following the IETD sequence in this substrate, AFC is released and emits fluorescence (Ex = ~400 nm; Em = ~505 nm) [1].
Product Specifications
UNSPSC
12352209
Target
Caspase
Related Pathways
Apoptosis
Field of Research
Others
Smiles
FC(C(O)=O)(F)F.FC(F)(C(C(C(O1)=C2)=CC=C2NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)[C@@H](C)CC)=O)=O)=O)=O)=CC1=O)F
Molecular Formula
C33H39F6N5O14
Molecular Weight
843.68
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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