Miuraenamide A

Miuraenamide A is an antifungal and antitumor antibiotic. Miuraenamide A is also an actin filament stabilizer. Miuraenamide A stabilizes actin filaments. Miuraenamide A exhibits potent antifungal activity, particularly against the phytopathogenic oomycete Phytophthora capsici[1][2].

Product Specifications

CAS Number

[905982-74-3]

Product Name Alternative

SMH 27-4A

UNSPSC

12352209

Target

Antibiotic; Arp2/3 Complex; Fungal

Related Pathways

Anti-infection; Cytoskeleton

Field of Research

Cancer; Infection

Smiles

CO/C(C1=CC=CC=C1)=C(NC([C@@H](CC2=CC=C(O)C(Br)=C2)N(C)C([C@H](C)N3)=O)=O)\C(O[C@H](CC/C(C)=C\CCCC3=O)C)=O

Molecular Formula

C34H42BrN3O7

Molecular Weight

684.62

References & Citations

[1]Sumiya E, et al. Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers. ACS Chem Biol. 2011 May 20;6 (5) :425-31. |[2]Liu Y, et al. Heterologous Biosynthesis of Myxobacterial Antibiotic Miuraenamide A. Molecules. 2023 Mar 20;28 (6) :2815.