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Cyclomarin monomer-2

Cyclomarin monomer-2 (Compound 10), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-2 binds to the Mtb ClpC1 protein with a KD of 4.0 nM. The MIC of Cyclomarin monomer-2 against the Mtb H37Rv standard strain is 3.1 μM. Cyclomarin monomer-2 can be used as a key intermediate in the development of Homo-BacPROTACs[1].

Product Specifications

UNSPSC

12352209

Target

Bacterial; Drug Intermediate

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

CN1C2=C(C(C[C@@H](C(N(C)[C@H]3C[C@H](CO)C)=O)NC([C@@H](NC([C@H](CC(C)C)N(C)C([C@H](C(C)C)NC([C@H]([C@H](OC)C4=CC=CC=C4)NC([C@@H](NC3=O)C)=O)=O)=O)=O)CC#C)=O)=C1)C=CC=C2

Molecular Formula

C49H68N8O9

Molecular Weight

913.11

References & Citations

[1]Junk L, et al. Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria. Nat Commun. 2024 Mar 5;15 (1) :2005

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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