Lytx-Pa2a

Lytx-Pa2a (Lycotoxin-Pa2a) is a peptide inhibitor against bacterial membranes and TLR4 receptor. Lytx-Pa2a exerts antimicrobial effects via non-competitive disruption of outer/cytoplasmic membranes and suppression of LPS-induced TLR4/NF-κB signaling. Lytx-Pa2a is promising for research of bacterial infection and inflammation-related disease (e.g., sepsis) [1].

Product Specifications

Product Name Alternative

Lycotoxin-Pa2a; TBIU041425

UNSPSC

12352209

Target

Bacterial; Toll-like Receptor (TLR)

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@H]3CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)NC4=O)C(N[C@@H]([C@@H](C)CC)C(N5[C@@H](CCC5)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CC7=CNC=N7)C(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]8CC9=CC=CC=C9)=O)NC%10=O)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@H]%10CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(N[C@H]4CSSC[C@@H](C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC%11=CNC=N%11)C(N[C@@H](CC%12=CNC=N%12)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC%13=CC=CC=C%13)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC%14=CC=CC=C%14)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC8=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N

Molecular Formula

C314H494N94O91S8

Molecular Weight

7298.38

References & Citations

[1]Shin MK, et al. The Identification of a Novel Spider Toxin Peptide, Lycotoxin-Pa2a, with Antibacterial and Anti-Inflammatory Activities. Antibiotics (Basel) . 2023 Dec 7;12 (12) :1708.