Epidermal mitosis inhibiting pentapeptide

Epidermal mitosis inhibiting pentapeptide is a five-peptide that acts as a physiological inhibitor of epidermal cell proliferation. This pentapeptide can significantly reduce the DNA synthesis rate and mitotic rate of epidermal keratinocytes. Epidermal mitosis inhibiting pentapeptide moderately enhances the occurrence of skin tumors in skin cancer models, but also shows a higher tendency to promote the regression of already formed tumors. Epidermal mitosis inhibiting pentapeptide can be hydrolyzed by angiotensin-converting enzyme (ACE) . Epidermal mitosis inhibiting pentapeptide can be used in cancer process research[1][2].

Product Specifications

CAS Number

[106678-69-7]

UNSPSC

12352209

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(NCC(O)=O)=O)=O)=O)[C@H](CC1)NC1=O

Molecular Formula

C19H27N5O12

Molecular Weight

517.44

References & Citations

[1]Bramucci M, et al. Presence and comparison of angiotensin converting enzyme in commercial cell culture sera. Biochem Mol Biol Int. 1999 Jan;47 (1) :107-15.|[2]Iversen OH, et al. Moderate enhancement of the promotion phase of skin tumorigenesis in hairless mice by topical pretreatment with a mitosis-inhibiting epidermal pentapeptide. Carcinogenesis. 1993 Dec;14 (12) :2537-42.