Ac-RGDS-NH2
Ac-RGDS-NH2, a tetrapeptide, is an integrin antagonist. Ac-RGDS-NH2 competitively binds to the GPIIb/IIIa receptor (Ki = 4.2 μM), inhibiting the binding of fibrinogen to platelets and thereby effectively suppressing platelet aggregation. Ac-RGDS-NH2 can be used for research on thrombosis[1].
Product Specifications
CAS Number
122207-62-9
UNSPSC
12352209
Target
Integrin
Related Pathways
Cytoskeleton
Field of Research
Cardiovascular Disease
Smiles
NC([C@H](CO)NC([C@H](CC(O)=O)NC(CNC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)=O)=O
Molecular Formula
C17H30N8O8
Molecular Weight
474.47
References & Citations
[1]Samanen J, et al. Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro. J Med Chem. 1991 Oct;34 (10) :3114-25.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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