Ac-RGDS-NH2

Ac-RGDS-NH2, a tetrapeptide, is an integrin antagonist. Ac-RGDS-NH2 competitively binds to the GPIIb/IIIa receptor (Ki = 4.2 μM), inhibiting the binding of fibrinogen to platelets and thereby effectively suppressing platelet aggregation. Ac-RGDS-NH2 can be used for research on thrombosis[1].

Product Specifications

CAS Number

[122207-62-9]

UNSPSC

12352209

Target

Integrin

Related Pathways

Cytoskeleton

Field of Research

Cardiovascular Disease

Smiles

NC([C@H](CO)NC([C@H](CC(O)=O)NC(CNC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)=O)=O

Molecular Formula

C17H30N8O8

Molecular Weight

474.47

References & Citations

[1]Samanen J, et al. Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro. J Med Chem. 1991 Oct;34 (10) :3114-25.