D-Phe-Pro-Arg-Chloromethylketone

D-Phe-Pro-Arg-Chloromethylketone is an irreversible thrombin inhibitor. D-Phe-Pro-Arg-Chloromethylketone inhibits human α-thrombin. D-Phe-Pro-Arg-Chloromethylketone can be covalently immobilized to PEGylated polymer thin films[1][2].

Product Specifications

CAS Number

[65149-23-7]

UNSPSC

12352209

Target

Biochemical Assay Reagents; Thrombin

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Smiles

O=C([C@@H]1CCCN1)N[C@H](C(N[C@H](C(CCl)=O)CCCNC(N)=N)=O)CC2=CC=CC=C2

Molecular Formula

C21H31ClN6O3

Molecular Weight

450.96

References & Citations

[1]Bode W, et al. The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Sci. 1992 Apr;1 (4) :426-71. |[2]Maitz MF, et al. Immobilization of the irreversible thrombin inhibitor D-Phe-Pro-Arg-chloromethylketone: a concept for hemocompatible surfaces? J Biomed Mater Res A. 2010 Sep 1;94 (3) :905-12.