Tachyplesin II

Tachyplesin II is a broad-spectrum cationic antimicrobial peptide. Tachyplesin II has significant inhibitory effects on Gram-positive bacteria, Gram-negative bacteria, and some fungi. Tachyplesin II binds to bacterial membrane lipopolysaccharides through its positive charge, disrupting membrane integrity and causing leakage of cellular contents. Tachyplesin II can bind to DNA grooves, inhibiting microbial replication, and also suppressing HIV-1 replication and the proliferation of liver cancer cells[1].

Product Specifications

UNSPSC

12352209

Target

Bacterial; DNA Alkylator/Crosslinker; Fungal; HIV

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Cancer; Infection

Smiles

O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)NC3=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3CCCCN)=O)=O)=O)NC6=O)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H]6[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N

Molecular Formula

C99H150N34O20S4

Molecular Weight

2264.73

References & Citations

[1]Xu F, et al. Eukaryotic expression and antimicrobial spectrum determination of the peptide tachyplesin II. Protein Expr Purif. 2008 Apr;58 (2) :175-83.