Metalnikowin I

Metalnikowin I (MetI) is a proline-rich antimicrobial peptide and DnaK inhibitor. Metalnikowin I can be derived from insects[1][2].

Product Specifications

CAS Number

[172430-37-4]

Product Name Alternative

MetI

UNSPSC

12352209

Target

Bacterial; HSP

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](CC(O)=O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CCCNC(N)=N)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(N6[C@@H](CCC6)C(N[C@@H](CC(N)=O)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N

Molecular Formula

C80H128N26O22S

Molecular Weight

1838.10

References & Citations

[1]Seefeldt AC, et al. Structure of the mammalian antimicrobial peptide Bac7 (1-16) bound within the exit tunnel of a bacterial ribosome. Nucleic Acids Res. 2016 Mar 18;44 (5) :2429-38. |[2]Welch NG, et al. (Re) Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members. Front Chem. 2020 Dec 1;8:607769.