(Sar1, Gly8) -Angiotensin II

(Sar1, Gly8) -Angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist (Ki: 52 nM for AT2 receptor in rat adrenal) . (Sar1, Gly8) -Angiotensin II potently antagonizes dipsogenic responses to intracerebroventricularly administered Ang II[1].

Product Specifications

CAS Number

[51887-62-8]

UNSPSC

12352209

Target

Angiotensin Receptor

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(NCC(O)=O)=O)=O)=O)=O

Molecular Formula

C42H65N13O10

Molecular Weight

912.05

References & Citations

[1]Speth RC. Sarcosine1, glycine8 angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist. Regul Pept. 2003 Oct 15;115 (3) :203-9.