THR-123
THR-123 is an orally active ALK3 peptide agonist. THR-123 has a relatively weak binding to ALK2, but does not bind to ALK6. THR-123 suppresses inflammation, apoptosis and the epithelial-to-mesenchymal transition program and reverses established fibrosis in five mouse models of acute and chronic renal injury. THR-123 can be used for the study of kidney fibrosis[1].
Product Specifications
UNSPSC
12352209
Target
Apoptosis; Cadherin; Integrin; Interleukin Related; TGF-β Receptor
Related Pathways
Apoptosis; Cytoskeleton; Immunology/Inflammation; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
Molecular Formula
C83H124N22O27S2
Molecular Weight
1926.13
References & Citations
[1]Sugimoto H, et al. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med. 2012 Feb 5;18 (3) :396-404.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
ALK3; IL-6; IL-8
Frequently Asked Questions
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