Ac-FR-AFC (TFA)

Ac-FR-AFC TFA is a Cathepsin L fluorogenic substrate (Ex=400 nm, Em=505 nm) . Cathepsin L activity in cells lysates is determined by measuring cleavage of Ac-FR-AFC TFA and its cleavage occurs at the FR-AFC amide bond. Ac-FR-AFC TFA can be used for activity assays and mechanistic studies on cathepsin L[1].

Product Specifications

UNSPSC

12352209

Target

Cathepsin; Fluorescent Dye

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Smiles

OC(C(F)(F)F)=O.NC(NCCC[C@H](NC([C@@H](NC(C)=O)CC1=CC=CC=C1)=O)C(NC2=CC=C(C(C(F)(F)F)=CC(O3)=O)C3=C2)=O)=N

Molecular Formula

C29H30F6N6O7

Molecular Weight

688.57

References & Citations

[1]Zhang X, et al. Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. J Exp Clin Cancer Res. 2017 Sep 5;36 (1) :118.