Ac-RR-AFC (TFA)

Ac-RR-AFC TFA is a Cathepsin B fluorogenic substrate (Ex=400 nm, Em=505 nm) . Cathepsin B activity in cells lysates is determined by measuring cleavage of Ac-RR-AFC TFA and its cleavage occurs at the RR-AFC amide bond. Ac-RR-AFC TFA can be used for activity assays and mechanistic studies on cathepsin B[1].

Product Specifications

UNSPSC

12352209

Target

Cathepsin; Fluorescent Dye

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Smiles

NC(NCCC[C@H](NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)C(NC1=CC=C(C(C(F)(F)F)=CC(O2)=O)C2=C1)=O)=N.OC(C(F)(F)F)=O

Molecular Formula

C26H33F6N9O7

Molecular Weight

697.59

References & Citations

[1]Zhang X, et al. Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. J Exp Clin Cancer Res. 2017 Sep 5;36 (1) :118.